The Rate Of Blood Coagulation Is Determined Genetically.
In an endeavour to uncover why some people's blood platelets pile faster than others, a genetic opinion has turned up a particular grouping of overactive genes that seems to check the process. On the with the addition of side, platelets are uncertain for fending off infections and healing wounds what is the name of herbal medicine of. On the down side, they can rush spirit disease, heart attacks and stroke, the go into authors noted.
The current declaration regarding the genetic roots driving platelet behavior comes from what is believed to be the largest assessment of the compassionate genetic code to date, according to co-senior on investigator Dr Lewis Becker, a cardiologist with the Johns Hopkins University School of Medicine provillus. "Our results give us a absolve set of redone molecular targets, the proteins produced from these genes, to originate tests that could assistance us identify plebeians more at risk for blood clots and for whom certain blood-thinning drugs may responsibility best or not," Becker said in a Johns Hopkins talk release.
So "We can even seem toward testing new treatments that may speediness up how the body fights infection or recovers from wounds," he added 4 rx day. The ruminate on findings were published online June 7 in Nature Genetics.
Showing posts with label platelet. Show all posts
Showing posts with label platelet. Show all posts
Tuesday, 28 January 2014
Sunday, 20 November 2011
The Problem Of Treating Patients With Heart Disease Who Do Not Respond To Plavix
The Problem Of Treating Patients With Heart Disease Who Do Not Respond To Plavix.
Higher doses of the blood-thinner Plavix were no better at preventing nerve attacks, blood clots or destruction than the pennant soften quantity in patients who had received artery-opening stents, original scrutiny shows. The higher amount - double-dealing the usual amount - was tested in patients with "high platelet reactivity," message they failed to rejoin to the drug at lower doses diax od medicine. Plavix (clopidogrel) helps obstruct clots from forming in patients who have indecent platelet reactivity and who have had stents inserted to stay open blocked arteries.
But the uncharted study "doesn't support" physicians using the higher, 150-milligram dosage of Plavix after stenting, according to inspect lead author Dr Matthew Price, who presented the findings Tuesday at the annual convention of the American Heart Association in Chicago. So, the con leaves an distinguished question unanswered: How to explore heart patients who don't come back well to Plavix? "It remains in the balance to some extent," said Dr Abhiram Prasad, an interventional cardiologist with the Mayo Clinic in Rochester, Minn Provillus mumbai. "It's an substantial studio to have done but the clue issues are that a significant proportion of the patients remained with lofty platelet reactivity even after being on the higher dose".
Previous, smaller studies had indicated that Plavix might have more of an impression if the dispense was doubled. "Platelet reactivity varies widely," illustrious Price, director of the Cardiac Catheterization Laboratory at the Scripps Clinic in La Jolla, Calif. He explained that numerous studies have shown that a on a trip reactivity supine is associated with poorer outcomes after angioplasty and/or stenting skin cancer buy medicine. But until now, a bury originate in the measure of Plavix "has not been tested in a overwhelmingly randomized clinical trial," he said.
Higher doses of the blood-thinner Plavix were no better at preventing nerve attacks, blood clots or destruction than the pennant soften quantity in patients who had received artery-opening stents, original scrutiny shows. The higher amount - double-dealing the usual amount - was tested in patients with "high platelet reactivity," message they failed to rejoin to the drug at lower doses diax od medicine. Plavix (clopidogrel) helps obstruct clots from forming in patients who have indecent platelet reactivity and who have had stents inserted to stay open blocked arteries.
But the uncharted study "doesn't support" physicians using the higher, 150-milligram dosage of Plavix after stenting, according to inspect lead author Dr Matthew Price, who presented the findings Tuesday at the annual convention of the American Heart Association in Chicago. So, the con leaves an distinguished question unanswered: How to explore heart patients who don't come back well to Plavix? "It remains in the balance to some extent," said Dr Abhiram Prasad, an interventional cardiologist with the Mayo Clinic in Rochester, Minn Provillus mumbai. "It's an substantial studio to have done but the clue issues are that a significant proportion of the patients remained with lofty platelet reactivity even after being on the higher dose".
Previous, smaller studies had indicated that Plavix might have more of an impression if the dispense was doubled. "Platelet reactivity varies widely," illustrious Price, director of the Cardiac Catheterization Laboratory at the Scripps Clinic in La Jolla, Calif. He explained that numerous studies have shown that a on a trip reactivity supine is associated with poorer outcomes after angioplasty and/or stenting skin cancer buy medicine. But until now, a bury originate in the measure of Plavix "has not been tested in a overwhelmingly randomized clinical trial," he said.
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